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BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial.
Pfisterer M, Buser P, Rickli H, Gutmann M, Erne P, Rickenbacher P, Vuillomenet A, Jeker U, Dubach P, Beer H, Yoon SI, Suter T, Osterhues HH, Schieber MM, Hilti P, Schindler R, Brunner-La Rocca HP; TIME-CHF Investigators. Pfisterer M, et al. JAMA. 2009 Jan 28;301(4):383-92. doi: 10.1001/jama.2009.2. JAMA. 2009. PMID: 19176440 Clinical Trial.