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202 results

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Page 1
Sensitization by ventral pallidal DAMGO: lack of cross-sensitization to morphine.
Rokosik SL, Persons AL, Napier TC. Rokosik SL, et al. Neuroreport. 2013 Feb 13;24(3):152-8. doi: 10.1097/WNR.0b013e32835e11a2. Neuroreport. 2013. PMID: 23337715
Although morphine and [D-Ala, N-MePhe, Gly(ol)]-enkephalin (DAMGO) both activate mu-opioid receptors, their influence on receptor-mediated signaling differs; therefore, we determined if they differentially influenced ventral pallidal-mediated motor sensitization. Re …
Although morphine and [D-Ala, N-MePhe, Gly(ol)]-enkephalin (DAMGO) both activate mu-opioid receptors, their influence on recep …
Age-related changes in peripheral nociceptor function.
Jennings EM, Sullivan LC, Jamshidi RJ, LoCoco PM, Smith HR, Chavera TS, Berg KA, Clarke WP. Jennings EM, et al. Neuropharmacology. 2022 Sep 15;216:109187. doi: 10.1016/j.neuropharm.2022.109187. Epub 2022 Jul 12. Neuropharmacology. 2022. PMID: 35835212
Intraplantar injection of TRP channel activators, capsaicin (TRPV1), mustard oil (TRPA1) and menthol (TRPM8) each resulted in greater mechanical allodynia in aged versus young rats and capsaicin-induced heat allodynia was also greater in aged rats. A treatment-induced …
Intraplantar injection of TRP channel activators, capsaicin (TRPV1), mustard oil (TRPA1) and menthol (TRPM8) each resulted in greater mechan …
CI-977, a novel and selective agonist for the kappa-opioid receptor.
Hunter JC, Leighton GE, Meecham KG, Boyle SJ, Horwell DC, Rees DC, Hughes J. Hunter JC, et al. Br J Pharmacol. 1990 Sep;101(1):183-9. doi: 10.1111/j.1476-5381.1990.tb12110.x. Br J Pharmacol. 1990. PMID: 2178014 Free PMC article.
In a radioligand binding studies, with guinea-pig forebrain homogenates, CI-977 bound with high affinity to [3H]-U69593-labelled kappa-sites (Ki = 0.11 nM) but with low affinity to [3H]-[D-Ala2, MePhe4, Gly-ol5] enkephalin (DAMGO) labelled mu-sites (Ki = 99 n …
In a radioligand binding studies, with guinea-pig forebrain homogenates, CI-977 bound with high affinity to [3H]-U69593-labelled kapp …
Optimization binding studies of opioid receptors, saturation and competition, using [(3)H]-DAMGO.
Khoramjouy M, Ahmadi F, Faizi M, Shahhosseini S. Khoramjouy M, et al. Pharmacol Rep. 2021 Oct;73(5):1390-1395. doi: 10.1007/s43440-021-00265-9. Epub 2021 Apr 19. Pharmacol Rep. 2021. PMID: 33871815
METHODS: We used the midbrain and brainstem of naltrexone-treated rats as a source of -opioid receptors, and [(3)H]-DAMGO as the radioligand. Naloxone was also used to determine non-specific binding. A given amount of membrane protein was incubated with an increasing amoun …
METHODS: We used the midbrain and brainstem of naltrexone-treated rats as a source of -opioid receptors, and [(3)H]-DAMGO as the radi …
DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens.
Al-Khrasani M, Spetea M, Friedmann T, Riba P, Király K, Schmidhammer H, Furst S. Al-Khrasani M, et al. Brain Res Bull. 2007 Oct 19;74(5):369-75. doi: 10.1016/j.brainresbull.2007.07.008. Epub 2007 Jul 30. Brain Res Bull. 2007. PMID: 17845912
Here, the antinociceptive effects of MOR agonists, the 6beta-glycine derivative of 14-O-methyloxymorphone (HS-731), DAMGO and morphine were evaluated in a mouse model of visceral pain. The abdominal acetic acid-induced writhing test was used to examine the periphera …
Here, the antinociceptive effects of MOR agonists, the 6beta-glycine derivative of 14-O-methyloxymorphone (HS-731), DAMGO and morphin …
Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPgammaS binding in mice with Oprm1 A112G.
Wang YJ, Huang P, Blendy JA, Liu-Chen LY. Wang YJ, et al. Addict Biol. 2014 May;19(3):354-61. doi: 10.1111/j.1369-1600.2012.00484.x. Epub 2012 Aug 2. Addict Biol. 2014. PMID: 22862850 Free PMC article.
We compared A/A and G/G mice in the MOPR-selective agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO)-stimulated [(35) S]GTPgammaS binding in brain regions by autoradiography. ...In the nucleus accumbens (NAc) core, female G/G mice displayed lower DAMGO-st …
We compared A/A and G/G mice in the MOPR-selective agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO)-stimulated [(35) S]GT …
Persistent inflammation selectively activates opioid-sensitive phasic-firing neurons within the vlPAG.
McPherson KB, Bouchet CA, Coutens B, Ingram SL. McPherson KB, et al. J Neurophysiol. 2023 May 1;129(5):1237-1248. doi: 10.1152/jn.00016.2023. Epub 2023 Apr 19. J Neurophysiol. 2023. PMID: 37073984 Free PMC article.
The ventrolateral periaqueductal gray (vlPAG) is a key brain area within the descending pain modulatory pathway and an important target for opioid-induced analgesia. The vlPAG contains heterogeneous neurons with respect to neurotransmitter content, receptor and channel exp …
The ventrolateral periaqueductal gray (vlPAG) is a key brain area within the descending pain modulatory pathway and an important target for …
A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation.
Degro CE, Jiménez-Vargas NN, Guzman-Rodriguez M, Schincariol H, Tsang Q, Reed DE, Lomax AE, Bunnett NW, Stein C, Vanner SJ. Degro CE, et al. Br J Pharmacol. 2025 Feb;182(3):581-595. doi: 10.1111/bph.17363. Epub 2024 Oct 13. Br J Pharmacol. 2025. PMID: 39396524
Cross-tolerance also occurred to fentanyl, but not to NFEPP. The MOR agonist DAMGO inhibited colonic afferent nerve activity in colitis mice exposed to chronic NFEPP, but not those from fentanyl-treated mice. Similarly, in patch-clamp recordings from isolated dorsal root g …
Cross-tolerance also occurred to fentanyl, but not to NFEPP. The MOR agonist DAMGO inhibited colonic afferent nerve activity in colit …
Intra-amygdalar injection of DAMGO: effects on c-Fos levels in brain sites associated with feeding behavior.
Levine AS, Olszewski PK, Mullett MA, Pomonis JD, Grace MK, Kotz CM, Billington CJ. Levine AS, et al. Brain Res. 2004 Jul 23;1015(1-2):9-14. doi: 10.1016/j.brainres.2004.04.039. Brain Res. 2004. PMID: 15223361
We also studied the effect of CeA-injected DAMGO on LiCl-induced increases in c-Fos IR in the amygdala. As was expected, intra-CeA injection of DAMGO increased food intake of rats over a 4-h period. ...We also found that intra-CeA injection of DAMGO, p …
We also studied the effect of CeA-injected DAMGO on LiCl-induced increases in c-Fos IR in the amygdala. As was expected, intra …
NMDA receptors modulate morphine-induced hyperthermia.
Rawls SM, Adler MW, Gaughan JP, Baron A, Geller EB, Cowan A. Rawls SM, et al. Brain Res. 2003 Sep 12;984(1-2):76-83. doi: 10.1016/s0006-8993(03)03093-2. Brain Res. 2003. PMID: 12932841
LY 235959 (1 mg/kg) depressed the hyperthermia caused by DAMGO (1 micro g/rat, i.c.v.), a selective mu agonist, confirming that NMDA receptor activation maximizes mu receptor-induced hyperthermia. ...These data indicate that NMDA receptors modulate morphine-induc …
LY 235959 (1 mg/kg) depressed the hyperthermia caused by DAMGO (1 micro g/rat, i.c.v.), a selective mu agonist, confirming that NMDA …
202 results