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. 2016 Dec 20;129(24):2967-2973.
doi: 10.4103/0366-6999.195474.

Epidemiological Study of Sepsis in China: Protocol of a Cross-sectional Survey

Yi Yang  1 , Jian-Feng Xie  1 , Kai-Jiang Yu  2 , Chen Yao  3 , Jian-Guo Li  4 , Xiang-Dong Guan  5 , Jing Yan  6 , Xiao-Chun Ma  7 , Yan Kang  8 , Cong-Shan Yang  1 , Xiao-Qing Yao  9 , Hong-Cai Shang  10 , Hai-Bo Qiu  1 ; for CHESS Study Investigators
Affiliations

Epidemiological Study of Sepsis in China: Protocol of a Cross-sectional Survey

Yi Yang et al. Chin Med J (Engl). .

Abstract

Background: Sepsis is the leading cause of death among critically ill patients. Herein, we conducted a national survey to provide data on epidemiology and treatment of sepsis in the clinical practice in China, which has no detailed epidemiological data available on sepsis.

Methods: This was a prospective cross-sectional survey from December 1, 2015 to January 31, 2016 in all provinces/municipalities of the mainland of China. The primary outcome of this study was the incidence of sepsis, and the secondary outcome was its etiology in China. Patients with sepsis admitted to the Intensive Care Units were included in this study. The demographic, physiological, bacteriological, and therapeutic data of these patients were recorded. The incidence of sepsis was estimated using the data from the sixth census in China, reported by the Chinese National Health and Family Planning Commission and the National Bureau of Statistics as the standard population. The independent risk factors for increased mortality from sepsis were calculated.

Conclusions: This study indicated the incidence and outcome of sepsis in China. It also showed the most common etiology of different sites and types of infection, which could guide empiric antibiotic therapy. Moreover, it provided information on the independent risk factors for increased mortality due to sepsis. The findings provide evidence to guide clinical management and may help improve the outcome in septic patients.

Trial registration: ClinicalTrials.gov, NCT02448472; https://clinicaltrials.gov/show/NCT02448472.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Detailed flowchart of the Chinese Epidemiological Study of Sepsis. ICU: Intensive Care Unit.
See this image and copyright information in PMC

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