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66 results

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Page 1
Antibiotic-free ocular sterilization while suppressing immune response to protect corneal transparency in infectious keratitis treatment.
Peng Y, Pang S, Zeng Y, Wei J, Lu J, Ruan Y, Hong X, He X, Chu X, Guo Y, Guo H, Qian S, Jiang Z, Jiang Z, Wang B. Peng Y, et al. J Control Release. 2024 Oct;374:563-576. doi: 10.1016/j.jconrel.2024.08.038. Epub 2024 Aug 30. J Control Release. 2024. PMID: 39186983
In this work, photodynamic metal organic frameworks (PCN-224) were used as drug carrier to load Pt NPs with catalase-like activity and anti-inflammatory drug (Dexamethasone, DXMS) for endogenous oxygen generation and reduced corneal damage, respectively. The photodynamic t …
In this work, photodynamic metal organic frameworks (PCN-224) were used as drug carrier to load Pt NPs with catalase-like activity and anti- …
Traditional Chinese medicine Youguiyin decoction ameliorate glucocorticoid-induced osteonecrosis in rat by modulating ROS/PHD2/HIF-1α oxidative stress signaling pathway in bone marrow mesenchymal stem cells.
Xi H, Chen H, Fu J, He S, Liu X, Sun G, Du B. Xi H, et al. Chin Med. 2025 May 3;20(1):55. doi: 10.1186/s13020-025-01113-1. Chin Med. 2025. PMID: 40319297 Free PMC article.
Rat bone marrow mesenchymal stem cells (BMSCs) were induced with dexamethasone (DXMS) for 24 h, followed by YGY medicated serum for 24 h. Significantly up- and down-regulated genes were detected by RNA sequencing. ...In addition, YGY medicated serum antagoniz …
Rat bone marrow mesenchymal stem cells (BMSCs) were induced with dexamethasone (DXMS) for 24 h, followed by YGY medicated seru …
[Protection Effect of Dexamethasone on the Memory Impairment and Neuronal Damage of Neonate Rats that Repeatedly Suffered Sevoflurane Exposure].
Han J, Ou CH. Han J, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Dec;50(6):852-858. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019. PMID: 31880117 Chinese.
METHODS: 5-days-old newborn SD rats were randomly divided into normal group (NC group) (10 rats), SEVO group (10 rats) and SEVO+DXMS group (10 rats). Rats of SEVO group and SEVO+DXMS group were exposed to 2.5% SEVO 2 h per day for 1 week, meanwhile the rats o …
METHODS: 5-days-old newborn SD rats were randomly divided into normal group (NC group) (10 rats), SEVO group (10 rats) and SEVO+DXMS …
Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.
Roberts VA, Pique ME, Hsu S, Li S, Slupphaug G, Rambo RP, Jamison JW, Liu T, Lee JH, Tainer JA, Ten Eyck LF, Woods VL Jr. Roberts VA, et al. Nucleic Acids Res. 2012 Jul;40(13):6070-81. doi: 10.1093/nar/gks291. Epub 2012 Apr 6. Nucleic Acids Res. 2012. PMID: 22492624 Free PMC article.
Our approach combines rigid-body computational docking with hydrogen/deuterium exchange mass spectrometry (DXMS). DXMS identifies solvent-exposed protein surfaces; docking is used to create a 3-dimensional model of the protein-DNA interaction. ...
Our approach combines rigid-body computational docking with hydrogen/deuterium exchange mass spectrometry (DXMS). DXMS identif …
HDX-MS guided drug discovery: small molecules and biopharmaceuticals.
Marciano DP, Dharmarajan V, Griffin PR. Marciano DP, et al. Curr Opin Struct Biol. 2014 Oct;28:105-11. doi: 10.1016/j.sbi.2014.08.007. Epub 2014 Aug 30. Curr Opin Struct Biol. 2014. PMID: 25179005 Free PMC article. Review.
Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS or DXMS) has emerged as an important tool for the development of small molecule therapeutics and biopharmaceuticals. ...
Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS or DXMS) has emerged as an important tool for the development of s …
Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS).
Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V. Hamuro Y, et al. J Mol Biol. 2002 Aug 23;321(4):703-14. doi: 10.1016/s0022-2836(02)00419-9. J Mol Biol. 2002. PMID: 12206784
We have used deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein. ...The second folded region contained a highly protected PKA …
We have used deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing fo …
On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.
Spraggon G, Pantazatos D, Klock HE, Wilson IA, Woods VL Jr, Lesley SA. Spraggon G, et al. Protein Sci. 2004 Dec;13(12):3187-99. doi: 10.1110/ps.04939904. Protein Sci. 2004. PMID: 15557262 Free PMC article.
However, analysis of the recombinant purified proteins using the technique of enhanced amide hydrogen/deuterium exchange mass spectroscopy (DXMS) revealed substantial regions of rapid amide deuterium hydrogen exchange, consistent with flexible regions of the structures. .. …
However, analysis of the recombinant purified proteins using the technique of enhanced amide hydrogen/deuterium exchange mass spectroscopy ( …
Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometry.
Sharma S, Zheng H, Huang YJ, Ertekin A, Hamuro Y, Rossi P, Tejero R, Acton TB, Xiao R, Jiang M, Zhao L, Ma LC, Swapna GV, Aramini JM, Montelione GT. Sharma S, et al. Proteins. 2009 Sep;76(4):882-94. doi: 10.1002/prot.22394. Proteins. 2009. PMID: 19306341 Free PMC article.
In this article, we demonstrate the application of (1)H/(2)H exchange mass spectrometry (DXMS) for the rapid identification of disordered segments of proteins and design of protein constructs that are more suitable for structural analysis by NMR. ...Truncated …
In this article, we demonstrate the application of (1)H/(2)H exchange mass spectrometry (DXMS) for the rapid identifica …
Combining H/D Exchange Mass Spectrometry and Computational Docking To Derive the Structure of Protein-Protein Complexes.
Roberts VA, Pique ME, Hsu S, Li S. Roberts VA, et al. Biochemistry. 2017 Dec 5;56(48):6329-6342. doi: 10.1021/acs.biochem.7b00643. Epub 2017 Nov 16. Biochemistry. 2017. PMID: 29099587
To derive the protein complex of the DNA-repair enzyme human uracil-DNA-glycosylase (hUNG) with its protein inhibitor (UGI), we combined rigid-body computational docking with hydrogen/deuterium exchange mass spectrometry (DXMS). Computational docking of the unbound protein …
To derive the protein complex of the DNA-repair enzyme human uracil-DNA-glycosylase (hUNG) with its protein inhibitor (UGI), we combined rig …
66 results