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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1864 2
1948 1
1950 1
1952 3
1953 2
1954 3
1955 1
1957 6
1959 2
1963 6
1964 15
1965 2
1967 1
1968 1
1969 4
1970 2
1971 3
1972 2
1973 7
1974 3
1975 9
1976 10
1977 18
1978 9
1979 9
1980 18
1981 21
1982 26
1983 33
1984 32
1985 48
1986 49
1987 53
1988 59
1989 69
1990 62
1991 68
1992 65
1993 70
1994 69
1995 87
1996 140
1997 259
1998 531
1999 698
2000 1050
2001 1164
2002 1334
2003 1302
2004 1329
2005 1395
2006 1345
2007 1399
2008 1448
2009 1414
2010 1437
2011 1554
2012 1675
2013 1558
2014 2193
2015 2638
2016 2842
2017 2793
2018 3051
2019 3201
2020 3253
2021 3444
2022 3118
2023 3104
2024 3072
2025 3406
2026 90

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51,186 results

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Page 1
Epithelial Plasticity during Liver Injury and Regeneration.
Gadd VL, Aleksieva N, Forbes SJ. Gadd VL, et al. Cell Stem Cell. 2020 Oct 1;27(4):557-573. doi: 10.1016/j.stem.2020.08.016. Epub 2020 Sep 23. Cell Stem Cell. 2020. PMID: 32971004 Free article. Review.
Following injury, the liver's epithelial cells regenerate efficiently with rapid proliferation of hepatocytes and biliary cells. ...In this review, we evaluate the experimental and clinical evidence for epithelial plasticity in the liver and how this influenc …
Following injury, the liver's epithelial cells regenerate efficiently with rapid proliferation of hepatocytes and biliary cell …
Living-donor liver transplantation: Right versus left.
Yagi S, Singhal A, Jung DH, Hashimoto K. Yagi S, et al. Int J Surg. 2020 Oct;82S:128-133. doi: 10.1016/j.ijsu.2020.06.022. Epub 2020 Jun 30. Int J Surg. 2020. PMID: 32619620 Free article.
A dilemma of graft selection between right or left livers occurs during the planning of living-donor liver transplantation (LDLT) as well as splitting a whole liver graft into full right/full left grafts in deceased-donor liver transplantation. The rig …
A dilemma of graft selection between right or left livers occurs during the planning of living-donor liver transplantation (LD …
ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice.
Fan W, Liu T, Chen W, Hammad S, Longerich T, Hausser I, Fu Y, Li N, He Y, Liu C, Zhang Y, Lian Q, Zhao X, Yan C, Li L, Yi C, Ling Z, Ma L, Zhao X, Xu H, Wang P, Cong M, You H, Liu Z, Wang Y, Chen J, Li D, Hui L, Dooley S, Hou J, Jia J, Sun B. Fan W, et al. Gastroenterology. 2019 Nov;157(5):1352-1367.e13. doi: 10.1053/j.gastro.2019.07.036. Epub 2019 Jul 27. Gastroenterology. 2019. PMID: 31362006 Free article.
ECM1 or soluble TGFBR2 (TGFB receptor 2) were expressed in livers of mice after injection of an adeno-associated virus vector. Liver fibrosis was induced by carbon tetrachloride (CCl(4)) administration. ...CCl(4)-induced liver fibrosis was accelerated in ECM1 …
ECM1 or soluble TGFBR2 (TGFB receptor 2) were expressed in livers of mice after injection of an adeno-associated virus vector. Liv …
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis.
Tu C, Qian C, Li S, Lin DY, Liu ZY, Ouyang WG, Kang XL, Chen F, Song S, Cai SQ. Tu C, et al. Nat Aging. 2025 Jun;5(6):1063-1078. doi: 10.1038/s43587-025-00862-w. Epub 2025 May 19. Nat Aging. 2025. PMID: 40389730
With increased age, the liver becomes more vulnerable to metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis. Deciphering the complex interplay between aging, the emergence of senescent cells in the liver and MASH fibrosis is critical for developin …
With increased age, the liver becomes more vulnerable to metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis. Decip …
Liver transplantation.
Neuberger J. Neuberger J. J Hepatol. 2000;32(1 Suppl):198-207. doi: 10.1016/s0168-8278(00)80426-2. J Hepatol. 2000. PMID: 10728805 Free article. Review.
Since the first human liver transplant done in 1963, the procedure has become a routine procedure with an excellent outcome in terms both of quality and of length of survival. ...One of the major challenges facing the transplant community is the shortage of donor organs: i …
Since the first human liver transplant done in 1963, the procedure has become a routine procedure with an excellent outcome in terms …
A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease.
Wang Y, Wang J, Zhou Z, Gu Y, Zhu X, Yi Z, Cao C, He L, Du Y, Guo H, Tian Y, Fan Z. Wang Y, et al. J Hepatol. 2025 Jun;82(6):1068-1079. doi: 10.1016/j.jhep.2024.11.052. Epub 2024 Dec 10. J Hepatol. 2025. PMID: 39667599 Free article.
RESULTS: We identified 1,126 rt-circRNAs in liver tissues from patients with MASLD. RCRIN was highly expressed in normal livers and was downregulated in MASLD livers. ...IMPACT AND IMPLICATIONS: Our finds reveal a novel mechanism connecting a read-through cir …
RESULTS: We identified 1,126 rt-circRNAs in liver tissues from patients with MASLD. RCRIN was highly expressed in normal livers …
Spatiotemporal liver dynamics shape hepatocellular heterogeneity and impact in vivo gene engineering.
Milani M, Starinieri F, Beretta S, Monti M, Canepari C, Marabotti F, Zambrano S, Mazza D, Fabiano A, Simoni C, Cammarota E, Volpin M, Bortolussi G, Russo F, Biffi M, Genua M, Degl'Innocenti S, Sanvito F, Ostuni R, Muro AF, Montini E, Moalli F, Iannacone M, Merelli I, Cantore A. Milani M, et al. J Hepatol. 2025 Dec;83(6):1392-1409. doi: 10.1016/j.jhep.2025.06.018. Epub 2025 Jul 3. J Hepatol. 2025. PMID: 40617259 Free PMC article.
BACKGROUND & AIMS: Hepatocytes are the liver's main functional cells and are key targets for in vivo gene therapy to treat monogenic diseases. ...Here, we investigate how hepatocyte heterogeneity evolves during liver growth and its implications for in viv …
BACKGROUND & AIMS: Hepatocytes are the liver's main functional cells and are key targets for in vivo gene therapy to treat …
CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status.
Ni Y, Zhuge F, Ni L, Nagata N, Yamashita T, Mukaida N, Kaneko S, Ota T, Nagashimada M. Ni Y, et al. Metabolism. 2022 Nov;136:155272. doi: 10.1016/j.metabol.2022.155272. Epub 2022 Jul 29. Metabolism. 2022. PMID: 35914622
Here, the roles of CX3CL1/CX3CR1 in the macrophage migration and polarization in the livers of NASH mice were investigated. METHODS AND RESULTS: The expression of Cx3cl1 and Cx3cr1 was markedly upregulated in the livers of lipotoxicity-induced NASH mice. CX3CR1 was …
Here, the roles of CX3CL1/CX3CR1 in the macrophage migration and polarization in the livers of NASH mice were investigated. METHODS A …
ZnR/GPR39 regulates hepatic insulin signaling, tunes liver bioenergetics and ROS production, and mitigates liver fibrosis and injury.
Shendge AK, Sekler I, Hershfinkel M. Shendge AK, et al. Redox Biol. 2024 Dec;78:103403. doi: 10.1016/j.redox.2024.103403. Epub 2024 Oct 18. Redox Biol. 2024. PMID: 39514940 Free PMC article.
Adequate supply of zinc is essential for hepatic function and its deficiency is associated with acute liver injury (ALI) and chronic nonalcoholic fatty liver disease (NAFLD). However, how zinc controls hepatic function is unknown. ...Our findings reveal a role of Zn …
Adequate supply of zinc is essential for hepatic function and its deficiency is associated with acute liver injury (ALI) and chronic …
Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling.
Shao W, Xu H, Zeng K, Ye M, Pei R, Wang K. Shao W, et al. Stem Cell Res Ther. 2025 Jan 26;16(1):27. doi: 10.1186/s13287-025-04139-2. Stem Cell Res Ther. 2025. PMID: 39865320 Free PMC article. Review.
Traditional cellular and animal models, while widely used, have significant limitations in replicating the liver's complex responses to various stressors. Liver organoids derived from human pluripotent stem cells, adult stem cells primary cells, or tissues ca …
Traditional cellular and animal models, while widely used, have significant limitations in replicating the liver's complex res …
51,186 results
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