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631 results

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Did you mean machineryacm (1 results)?
Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy.
Liu L, Yu L, Wang Y, Zhou L, Liu Y, Pan X, Huang J. Liu L, et al. Pharmacol Res. 2024 Sep;207:107305. doi: 10.1016/j.phrs.2024.107305. Epub 2024 Jul 11. Pharmacol Res. 2024. PMID: 39002868 Free article. Review.
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic and epigenetic dysregulation playing a pivotal role in its pathogenesis. ...Importantly, aberrations in the RNA methylation machinery ha …
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic and …
Iron and Immunity.
Verbon EH, Trapet PL, Stringlis IA, Kruijs S, Bakker PAHM, Pieterse CMJ. Verbon EH, et al. Annu Rev Phytopathol. 2017 Aug 4;55:355-375. doi: 10.1146/annurev-phyto-080516-035537. Epub 2017 Jun 9. Annu Rev Phytopathol. 2017. PMID: 28598721 Review.
They compete for iron with soil-borne pathogens or induce a systemic resistance that shares early signaling components with the root iron-uptake machinery. This review describes the progress in our understanding of the role of iron homeostasis in both pathogenic and benefi …
They compete for iron with soil-borne pathogens or induce a systemic resistance that shares early signaling components with the root iron-up …
The LC3-conjugation machinery specifies cargo loading and secretion of extracellular vesicles.
Delorme-Axford E, Klionsky DJ. Delorme-Axford E, et al. Autophagy. 2020 Jul;16(7):1169-1171. doi: 10.1080/15548627.2020.1760057. Epub 2020 May 13. Autophagy. 2020. PMID: 32401566 Free PMC article.
A recent study published in Nature Cell Biology from the laboratory of Jayanta Debnath has identified components of the LC3-conjugation machinery as mediators in the selection of cargo for nonclassical secretion. Termed LC3-dependent extracellular vesicle loading and secre …
A recent study published in Nature Cell Biology from the laboratory of Jayanta Debnath has identified components of the LC3-conjugation m …
Molecular classification and biomarkers of outcome with immunotherapy in extensive-stage small-cell lung cancer: analyses of the CASPIAN phase 3 study.
Xie M, Vuko M, Rodriguez-Canales J, Zimmermann J, Schick M, O'Brien C, Paz-Ares L, Goldman JW, Garassino MC, Gay CM, Heymach JV, Jiang H, Barrett JC, Stewart RA, Lai Z, Byers LA, Rudin CM, Shrestha Y. Xie M, et al. Mol Cancer. 2024 May 30;23(1):115. doi: 10.1186/s12943-024-02014-x. Mol Cancer. 2024. PMID: 38811992 Free PMC article. Clinical Trial.
OS benefit with D + T + EP versus D + EP was associated with high expression of CD4 (median 25.9 vs. 11.4 months) and antigen-presenting and processing machinery (25.9 vs. 14.6 months) and MHC I and II (23.6 vs. 17.3 months) gene signatures, and with higher MHC I expressio …
OS benefit with D + T + EP versus D + EP was associated with high expression of CD4 (median 25.9 vs. 11.4 months) and antigen-presenting and …
CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
Meijboom KE, Abdallah A, Fordham NP, Nagase H, Rodriguez T, Kraus C, Gendron TF, Krishnan G, Esanov R, Andrade NS, Rybin MJ, Ramic M, Stephens ZD, Edraki A, Blackwood MT, Kahriman A, Henninger N, Kocher JA, Benatar M, Brodsky MH, Petrucelli L, Gao FB, Sontheimer EJ, Brown RH, Zeier Z, Mueller C. Meijboom KE, et al. Nat Commun. 2022 Oct 21;13(1):6286. doi: 10.1038/s41467-022-33332-7. Nat Commun. 2022. PMID: 36271076 Free PMC article.
Here, we used an adeno-associated viral vector system to deliver CRISPR/Cas9 gene-editing machineries to effectuate the removal of the HRE from the C9ORF72 genomic locus. We demonstrate successful excision of the HRE in primary cortical neurons and brains of three mouse mo …
Here, we used an adeno-associated viral vector system to deliver CRISPR/Cas9 gene-editing machineries to effectuate the removal of th …
Emissions of air pollutants from non-road construction machinery in Beijing from 2015 to 2019.
Li X, Yang L, Liu Y, Zhang C, Xu X, Mao H, Jin T. Li X, et al. Environ Pollut. 2023 Jan 15;317:120729. doi: 10.1016/j.envpol.2022.120729. Epub 2022 Nov 22. Environ Pollut. 2023. PMID: 36427826
Construction machinery (CM) is considered to be a significant source of air pollution. The estimation of emissions from CM is essential for policy-makers to control air pollution and reduce carbon emissions. ...Machinery with a mean power above 75 kW a …
Construction machinery (CM) is considered to be a significant source of air pollution. The estimation of emissions from CM …
TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts.
Ly T, Pickard B, Pandey A, Yap M, Opara J, Arnold L, Martinez-Rivera N, Rosa-Molinar E, New J, Werner L, Farrokhian N, Gunewardena S, O'Neil M, Bur A, Anant S, Washburn MP, Barnaba C, Ding WX, Thomas SM. Ly T, et al. Autophagy. 2025 Nov;21(11):2473-2496. doi: 10.1080/15548627.2025.2508064. Epub 2025 May 22. Autophagy. 2025. PMID: 40383937 Free PMC article.
Despite the significant role of secretory autophagy in CAFs, its molecular machinery has remained elusive. Using both a literature based, and an unbiased approach, we studied the molecular machinery involved in autophagosome trafficking in CAFs. ...These findings un …
Despite the significant role of secretory autophagy in CAFs, its molecular machinery has remained elusive. Using both a literature ba …
Adipocytes reprogram prostate cancer stem cell machinery.
Fontana F, Anselmi M, Limonta P. Fontana F, et al. J Cell Commun Signal. 2023 Sep;17(3):915-924. doi: 10.1007/s12079-023-00738-x. Epub 2023 Mar 20. J Cell Commun Signal. 2023. PMID: 36940071 Free PMC article.
Herein, we demonstrated that 3T3-L1 adipocyte conditioned media (CM) could endow PC3 and DU145 PCa cells with stemness properties, by stimulating their sphere formation ability and promoting CD133 and CD44 expression. Moreover, after exposure to adipocyte CM both PC …
Herein, we demonstrated that 3T3-L1 adipocyte conditioned media (CM) could endow PC3 and DU145 PCa cells with stemness properties, by …
RNA epigenetic modifications in digestive tract cancers: Friends or foes.
Nian Z, Deng M, Ye L, Tong X, Xu Y, Xu Y, Chen R, Wang Y, Mao F, Xu C, Lu R, Mao Y, Xu H, Shen X, Xue X, Guo G. Nian Z, et al. Pharmacol Res. 2024 Aug;206:107280. doi: 10.1016/j.phrs.2024.107280. Epub 2024 Jun 22. Pharmacol Res. 2024. PMID: 38914382 Free article. Review.
Modulation of tumor microenvironment by targeting histone acetylation in bladder cancer.
Nunes SP, Morales L, Rubio C, Munera-Maravilla E, Lodewijk I, Suárez-Cabrera C, Martínez VG, Pérez-Escavy M, Pérez-Crespo M, Alonso Sánchez M, Montesinos E, San José-Enériz E, Agirre X, Prósper F, Pineda-Lucena A, Henrique R, Dueñas M, Correia MP, Jerónimo C, Paramio JM. Nunes SP, et al. Cell Death Discov. 2024 Jan 4;10(1):1. doi: 10.1038/s41420-023-01786-3. Cell Death Discov. 2024. PMID: 38172127 Free PMC article.
Here, we have explored the effects of a novel histone deacetylase (HDAC) inhibitor CM-1758, alone or in combination with immune checkpoint inhibitors (ICI) in BC. We determined the antitumor effects of CM-1758 in various BC cell lines together with the induction of …
Here, we have explored the effects of a novel histone deacetylase (HDAC) inhibitor CM-1758, alone or in combination with immune check …
631 results