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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
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1970 1
1971 2
1972 1
1973 1
1974 5
1975 4
1976 3
1977 9
1978 8
1979 5
1980 5
1981 5
1982 7
1983 8
1984 11
1985 7
1986 12
1987 11
1988 17
1989 18
1990 14
1991 21
1992 26
1993 26
1994 29
1995 40
1996 36
1997 39
1998 40
1999 39
2000 41
2001 53
2002 34
2003 45
2004 51
2005 56
2006 41
2007 47
2008 39
2009 48
2010 51
2011 40
2012 52
2013 38
2014 49
2015 50
2016 44
2017 31
2018 38
2019 27
2020 39
2021 44
2022 24
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2026 1

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1,428 results

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Page 1
Calcium channel gating.
Hering S, Zangerl-Plessl EM, Beyl S, Hohaus A, Andranovits S, Timin EN. Hering S, et al. Pflugers Arch. 2018 Sep;470(9):1291-1309. doi: 10.1007/s00424-018-2163-7. Epub 2018 Jun 27. Pflugers Arch. 2018. PMID: 29951751 Free PMC article. Review.
Tuned calcium entry through voltage-gated calcium channels is a key requirement for many cellular functions. This is ensured by channel gates which open during membrane depolarizations and seal the pore at rest. The gating process is determined by distinct sub-processes: m …
Tuned calcium entry through voltage-gated calcium channels is a key requirement for many cellular functions. This is ensured by channel gate …
New aspects in cardiac L-type Ca2+ channel regulation.
Pallien T, Klussmann E. Pallien T, et al. Biochem Soc Trans. 2020 Feb 28;48(1):39-49. doi: 10.1042/BST20190229. Biochem Soc Trans. 2020. PMID: 32065210 Review.
Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization. ...W …
Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L- …
Neuronal L-type calcium channels open quickly and are inhibited slowly.
Helton TD, Xu W, Lipscombe D. Helton TD, et al. J Neurosci. 2005 Nov 2;25(44):10247-51. doi: 10.1523/JNEUROSCI.1089-05.2005. J Neurosci. 2005. PMID: 16267232 Free PMC article.
Neuronal L-type calcium channels are essential for regulating activity-dependent gene expression, but they are thought to open too slowly to contribute to action potential-dependent calcium entry. ...We show that these channels open with fast kinetics and car …
Neuronal L-type calcium channels are essential for regulating activity-dependent gene expression, but they are thought to open …
Glutathionylation of the L-type Ca2+ channel in oxidative stress-induced pathology of the heart.
Johnstone VP, Hool LC. Johnstone VP, et al. Int J Mol Sci. 2014 Oct 22;15(10):19203-25. doi: 10.3390/ijms151019203. Int J Mol Sci. 2014. PMID: 25340983 Free PMC article. Review.
Ca2+ influx via the L-type Ca2+ channel increases production of mitochondrial reactive oxygen species (ROS) in cardiomyocytes during periods of oxidative stress. This induces a persistent increase in channel open probability, and the resulting constitutive increase …
Ca2+ influx via the L-type Ca2+ channel increases production of mitochondrial reactive oxygen species (ROS) in cardiomyocytes during …
Structural insights into the human system y(+)L amino acid transporter complex.
Dai L, Xu K, Zhang T, Wang X, Zeng Q, Liang H, Xu C, Yang L, Wang Z, Yan R. Dai L, et al. Structure. 2025 Jul 3;33(7):1224-1232.e5. doi: 10.1016/j.str.2025.04.012. Epub 2025 May 9. Structure. 2025. PMID: 40347950
System y(+)L consists of either SLC7A6 (y(+)LAT2) or SLC7A7 (y(+)LAT1) and 4F2hc (SLC3A2). The y(+)LAT2-4F2hc complex mediates the exchange of (L)-lysine (Lys), (L)-arginine (Arg), (L)-leucine (Leu), and (L)-glutamine (Gln) and is important for …
System y(+)L consists of either SLC7A6 (y(+)LAT2) or SLC7A7 (y(+)LAT1) and 4F2hc (SLC3A2). The y(+)LAT2-4F2hc complex mediates the ex …
L-type calcium channel targeting and local signalling in cardiac myocytes.
Shaw RM, Colecraft HM. Shaw RM, et al. Cardiovasc Res. 2013 May 1;98(2):177-86. doi: 10.1093/cvr/cvt021. Epub 2013 Feb 14. Cardiovasc Res. 2013. PMID: 23417040 Free PMC article. Review.
In the heart, Ca(2+) influx via Ca(V)1.2 L-type calcium channels (LTCCs) is a multi-functional signal that triggers muscle contraction, controls action potential duration, and regulates gene expression. ...This rapid cycling raises the question as to how cardiac myocytes d …
In the heart, Ca(2+) influx via Ca(V)1.2 L-type calcium channels (LTCCs) is a multi-functional signal that triggers muscle contractio …
Molecular aspects of adrenergic modulation of cardiac L-type Ca2+ channels.
van der Heyden MA, Wijnhoven TJ, Opthof T. van der Heyden MA, et al. Cardiovasc Res. 2005 Jan 1;65(1):28-39. doi: 10.1016/j.cardiores.2004.09.028. Cardiovasc Res. 2005. PMID: 15621031 Review.
L-type Ca(2+) channels are predominantly regulated by beta-adrenergic stimulation, enhancing L-type Ca(2+) current by increasing the mean channel open time and/or the opening probability of functional Ca(2+) channels. ...Other signaling intermediates (protein …
L-type Ca(2+) channels are predominantly regulated by beta-adrenergic stimulation, enhancing L-type Ca(2+) current by increasi …
Non-ionotropic voltage-gated calcium channel signaling.
Trus M, Atlas D. Trus M, et al. Channels (Austin). 2024 Dec;18(1):2341077. doi: 10.1080/19336950.2024.2341077. Epub 2024 Apr 11. Channels (Austin). 2024. PMID: 38601983 Free PMC article. Review.
Analogous to the "non-canonical" characterization of the non-ionotropic signaling exhibited by the N-methyl-D-aspartate receptor (NMDA), which requires extracellular Ca(2+) without the influx of ions, VGCC activation requires depolarization-triggered conformational change(s) conc …
Analogous to the "non-canonical" characterization of the non-ionotropic signaling exhibited by the N-methyl-D-aspartate receptor (NMDA), whi …
Tyrosine kinase inhibitors and ATP modulate the conversion of smooth muscle L-type Ca2+ channels toward a second open state.
Nakayama S, Ito Y, Sato S, Kamijo A, Liu HN, Kajioka S. Nakayama S, et al. FASEB J. 2006 Jul;20(9):1492-4. doi: 10.1096/fj.05-5049fje. Epub 2006 May 31. FASEB J. 2006. PMID: 16738256
Properties of smooth and cardiac L-type Ca2+ channels differ prominently in several physiological aspects, including sympathetic modulation. To assess the possible underlying mechanisms, we applied the whole cell patch-clamp technique to guinea pig detrusor smooth muscle c …
Properties of smooth and cardiac L-type Ca2+ channels differ prominently in several physiological aspects, including sympathetic modu …
Increased open probability of single cardiac L-type calcium channels in patients with chronic atrial fibrillation. role of phosphatase 2A.
Klein G, Schröder F, Vogler D, Schaefer A, Haverich A, Schieffer B, Korte T, Drexler H. Klein G, et al. Cardiovasc Res. 2003 Jul 1;59(1):37-45. doi: 10.1016/s0008-6363(03)00357-2. Cardiovasc Res. 2003. PMID: 12829174
BACKGROUND: The L-type calcium channel (LCC) plays a crucial role in the electrical remodeling of atrial fibrillation (AF). ...Single channel peak average current was 1.7-fold higher in AF than in SR, due to a 3.1-fold higher open probability of LCC. Since phosphata …
BACKGROUND: The L-type calcium channel (LCC) plays a crucial role in the electrical remodeling of atrial fibrillation (AF). ...Single …
1,428 results