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1,222 results

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Page 1
Membrane fusion: grappling with SNARE and SM proteins.
Südhof TC, Rothman JE. Südhof TC, et al. Science. 2009 Jan 23;323(5913):474-7. doi: 10.1126/science.1161748. Science. 2009. PMID: 19164740 Free PMC article. Review.
The two universally required components of the intracellular membrane fusion machinery, SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular and target membrane-localized SNARE proteins zipper up into an alpha-helical …
The two universally required components of the intracellular membrane fusion machinery, SNARE and SM (Sec1/Munc18-like) proteins …
Molecular Mechanisms Underlying Neurotransmitter Release.
Rizo J. Rizo J. Annu Rev Biophys. 2022 May 9;51:377-408. doi: 10.1146/annurev-biophys-111821-104732. Epub 2022 Feb 15. Annu Rev Biophys. 2022. PMID: 35167762 Free PMC article. Review.
Major recent advances and previous data have led to a plausible model of how key proteins mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) proteins syntaxin-1, SNAP …
Major recent advances and previous data have led to a plausible model of how key proteins mediate neurotransmitter release. In this m …
SNARE Complex-Associated Proteins and Alcohol.
Das J. Das J. Alcohol Clin Exp Res. 2020 Jan;44(1):7-18. doi: 10.1111/acer.14238. Epub 2019 Dec 11. Alcohol Clin Exp Res. 2020. PMID: 31724225 Free PMC article. Review.
This article is an endeavor in this direction, focusing on the effect of EtOH on the presynaptic proteins associated with the neurotransmitter release machinery. Studies on the effects of EtOH at the levels of gene, protein, and behavior are highlighted in this article....
This article is an endeavor in this direction, focusing on the effect of EtOH on the presynaptic proteins associated with the neurotr …
Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes.
Meijer M, Öttl M, Yang J, Subkhangulova A, Kumar A, Feng Z, van Voorst TW, Groffen AJ, van Weering JRT, Zhang Y, Verhage M. Meijer M, et al. Nat Commun. 2024 Mar 26;15(1):2652. doi: 10.1038/s41467-024-46828-1. Nat Commun. 2024. PMID: 38531902 Free PMC article.
While wild-type tomosyn-1m rescued these phenotypes, substitution of its SNARE motif with that of synaptobrevin-2/VAMP2 did not. Single-molecule force measurements indeed revealed that tomosyn's SNARE motif cannot substitute synaptobrevin-2/VAMP2 to form template co …
While wild-type tomosyn-1m rescued these phenotypes, substitution of its SNARE motif with that of synaptobrevin-2/VAMP2 did not. Sing …
Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission.
White KI, Khan YA, Qiu K, Balaji A, Couoh-Cardel S, Esquivies L, Pfuetzner RA, Diao J, Brunger AT. White KI, et al. Nat Commun. 2025 Sep 24;16(1):8371. doi: 10.1038/s41467-025-62764-0. Nat Commun. 2025. PMID: 40993127 Free PMC article.
Synaptic vesicles containing neurotransmitters fuse with the plasma membrane upon the arrival of an action potential at the active zone. Multiple proteins organize trans-SNARE complex assembly and priming, leading to fusion. One target membrane SNARE, syntaxi …
Synaptic vesicles containing neurotransmitters fuse with the plasma membrane upon the arrival of an action potential at the active zone. Mul …
Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila.
Chaudhry N, Sica M, Surabhi S, Hernandez DS, Mesquita A, Selimovic A, Riaz A, Lescat L, Bai H, MacIntosh GC, Jenny A. Chaudhry N, et al. Autophagy. 2022 Oct;18(10):2443-2458. doi: 10.1080/15548627.2022.2038999. Epub 2022 Mar 10. Autophagy. 2022. PMID: 35266854 Free PMC article.
In mammalian cells, loss of the lysosome associated membrane proteins LAMP1 and LAMP2 strongly affects autophagy and cholesterol trafficking. Here we show that the previously uncharacterized Drosophila Lamp1 is a bona fide ortholog of vertebrate LAMP1 and LAMP2. ...AP and …
In mammalian cells, loss of the lysosome associated membrane proteins LAMP1 and LAMP2 strongly affects autophagy and cholesterol traf …
"Kiss-shrink-run" unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling.
Tao CL, Tian CL, Liu YT, Lu ZH, Qi L, Li XW, Li C, Shen X, Gu ML, Huang WL, Liu S, Yang LQ, Liao Z, Ma X, Wu J, Sun J, Wang P, Lau PM, Zhou ZH, Bi GQ. Tao CL, et al. Science. 2025 Oct 16;390(6770):eads7954. doi: 10.1126/science.ads7954. Epub 2025 Oct 16. Science. 2025. PMID: 41100620
Within 4 milliseconds of synaptic activation, SVs transiently "kiss" the plasma membrane, forming a ~4-nanometer lipidic fusion pore flanked by putative soluble NSF-attachment protein receptor (SNARE) complexes and then rapidly "shrink" to approximately half of their origi …
Within 4 milliseconds of synaptic activation, SVs transiently "kiss" the plasma membrane, forming a ~4-nanometer lipidic fusion pore flanked …
The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins.
Usher S, Toulmé E, Florea R, Yatskevich S, Jao CC, Dijkhof LRH, Colding JM, Joshi P, Zilberleyb I, Trimbuch T, Brokowski B, Hauser AS, Leitner A, Rosenmund C, Kschonsak M, Pless SA. Usher S, et al. Sci Adv. 2025 Mar 14;11(11):eads6004. doi: 10.1126/sciadv.ads6004. Epub 2025 Mar 14. Sci Adv. 2025. PMID: 40085699 Free article.
NALCN (sodium leak channel, nonselective) is vital for regulating electrical activity in neurons and other excitable cells, and mutations in the channel or its auxiliary proteins lead to severe neurodevelopmental disorders. Here, we show that the neuronal SNARE (sol …
NALCN (sodium leak channel, nonselective) is vital for regulating electrical activity in neurons and other excitable cells, and mutations in …
v-SNARE function in chromaffin cells.
Dhara M, Mohrmann R, Bruns D. Dhara M, et al. Pflugers Arch. 2018 Jan;470(1):169-180. doi: 10.1007/s00424-017-2066-z. Epub 2017 Sep 8. Pflugers Arch. 2018. PMID: 28887593 Free PMC article. Review.
The machinery for vesicular release employs common molecular players in different model systems including neuronal and neuroendocrine cells, in particular members of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) protein family, Sec1/Mun …
The machinery for vesicular release employs common molecular players in different model systems including neuronal and neuroendocrine cells, …
Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.
Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C. Zhang H, et al. Sci Adv. 2024 May 17;10(20):eadi7024. doi: 10.1126/sciadv.adi7024. Epub 2024 May 17. Sci Adv. 2024. PMID: 38758791 Free PMC article.
At the synapse, presynaptic neurotransmitter release is tightly controlled by release machinery, involving the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins and Munc13. The Ca(2+) sensor Doc2 cooperates with Munc13 to regulat …
At the synapse, presynaptic neurotransmitter release is tightly controlled by release machinery, involving the soluble N-ethylmaleimide-sens …
1,222 results